Inter Milan midfielder Kwadwo Asamoah will be starting for Ghana when they come face to face with their Camerounian counterparts as the Stars seek to progress to the next stage of the competition and put their quest to win the trophy on cause.
Kwadwo Asamoah was given the chance following the injury of Thomas Agyepong.
Reims star Baba Rahman comes in for Lumor Agbeyenu in defence while Jonathan Mensah replaces suspended John Boye.
The match will kick off at the Ismailia Stadium at 5pm.
Ghana were surprisingly held to a 2-2 draw by Benin while Cameroun beat Guinea Bissau 2-0 in their opening game.
Below is Ghana's line-up.