Raheem Sterling scored two and set up three more as Manchester City let rip on Southampton
It came as an own goal as Wesley Hoedt tried to cut out Leroy Sane's cross in the direction of Raheem Sterling.
It was 2-0 in the 12th minute as City punished more hesitant defending. Sterling drove at goal and pulled three Saints defenders with him before his low cross was lashed home by Aguero.
It was the Argentinian's 150th Premier League goal for City, putting him joint-eighth alongside Michael Owen in the league's scoring charts.
It was quickly becoming a rout as David Silva made it 3-0 in the 18th minute smashing a shot into the roof of the net at the far post after Jack Stephens got a touch to Sterling's cross to keep it off the head of Sane.
Watch highlights of the match below;
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Danny Ings scored what was already a consolation from the penalty spot as Sterling restored City's three-goal advantage in first-half stoppage time.
Aguero did well to keep the ball in before rolling it across the area. Sterling's first touch was far from what he intended but his second found the net.
Just after the hour mark, Sane rattled the post with a powerful curling effort from the right of the area, with Alex McCarthy well beaten.
The fifth goal was coming and it duly arrived in the 67th minute. Aguero slipped the ball into the path of Sterling on the right of the area, and he drilled the ball under McCarthy for his second of the match.
Leroy Sane made it six in stoppage to complete a stunning performance.