Prime Minister Theresa May has won a vote of confidence in her leadership of the Conservative Party by 200 to 117.
After securing 63% of the total vote, she is now immune from a leadership challenge for a year.
Speaking in Downing Street, she vowed to deliver the Brexit "people voted for" but said she had listened to the concerns of MPs who voted against her.
Her supporters urged the party to move on but critics said losing the support of a third of MPs was "devastating".
The prime minister won the confidence vote with a majority of 83, with 63% of Conservative MPs backing her and 37% voting against her.
Ghana News Headlines
For today's latest Ghana news, visit Graphic Online headlines page Ghana news headlines.
The secret ballot was triggered by 48 of her MPs angry at her Brexit policy, which they say betrays the 2016 referendum result.
The BBC's Laura Kuenssberg said the level of opposition was "not at all comfortable" for the prime minister and a "real blow" to her authority.
Speaking shortly after the result was announced, Mrs May said she would be fighting for changes to her Brexit deal at an EU summit on Thursday.
"I am pleased to have received the backing of my colleagues in tonight's ballot," she said.
"Whilst I am grateful for that support, a significant number of colleagues did cast a vote against me and I have listened to what they said."
She spoke of a "renewed mission - delivering the Brexit people voted for, bringing the country back together and building a country that really works for everyone".