VIDEO: Liverpool climb top with 4-1 Cardiff victory
Liverpool manager Jurgen Klopp says it is "not too decisive" that the Reds are top of the table after 10 games as over Cardiff City ensured their joint-best start to a Premier League season
Mane scored twice while Mohamed Salah and substitute Xherdan Shaqiri also found the net at Anfield.
Unbeaten Liverpool's eighth top-flight win sent them three points clear of Manchester City, who do not play until Monday when they face fifth-placed Tottenham at Wembley.
Having also drawn two matches, Liverpool 26 points - matching their tally from the 2008-09 campaign, when they finished second.
Watch highlights of the match below;
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"Not too decisive but 26 points is good," Liverpool boss Klopp told BBC Sport when asked about going top.
The German joked: "In my whole life I wanted to be top for 24 hours."
Cardiff trailed to Salah's sweeping finish before Mane turned a couple of Cardiff defenders and finished past Neil Etheridge.
Virgil van Dijk nodded against a post while Adam Lallana was denied by Sean Morrison's headed clearance off the line as the Reds enjoyed 80% possession.
Cardiff pulled a goal back with their first shot on target 13 minutes from time, Callum Paterson steering past Alisson.
But substitute Shaqiri restored the two-goal cushion with his first goal for the club and Mane clipped past Etheridge to seal the points.