VIDEO: Juventus 1-2 Ajax
Ajax's sensational Champions League run continued as teenage captain Matthijs de goal eliminated Juventus and secured their place in the semi-finals
Ronaldo, a five-time winner of the tournament, headed the hosts in front from a first-half corner.
But Ajax battled level as Donny van de Beek controlled Hakim Ziyech's shot and slotted past Wojciech Szczesny.
Ziyech went close after the break before De , up from the back, scored a decisive, powerful header.
The away-goals rule left Juventus needing two in the remaining 23 minutes, but it could have been even more comfortable for the visitors in the closing stages with David Neres shooting wide and Ziyech flagged offside after whipping a smart shot into the top corner.
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Ronaldo, who picked up a late yellow card for a frustrated lunge at Joel , stalked off the pitch at the final whistle, having been knocked out of the competition for the first time since Juventus beat his previous club Real Madrid in May 2015.
Meanwhile, as they did after their sensational away win over Real Madrid in the previous round, Ajax's youthful side bounced in front of their raucous band of supporters and home fans streamed out the exits.
Ajax will face the winner of Manchester City and Tottenham's quarter-final, which Spurs lead 1-0 before Wednesday's second leg at Etihad Stadium.
Watch highlights of the match below;