Coach Kwasi Appiah has named his team for the Black Stars' Group F opener against Benin without experienced duo of Asamoah Gyan and Kwadwo Asamoah.
The two aces have been confined to a strong Ghana bench which has Samuel Owusu, Caleb Ekuban, Afriyie Acquah and others.
The Black Stars are determined to make a head start ahead of their epic clash with defending champions, Cameroun, on Saturday, June 29.
Ghana will play their last group match against Guinea-Bissau next Tuesday, July 2.
Richard Ofori, Andy Yiadom, Lumor Agbenyenu, John Boye,Nuhu Kassim, Mubarak Wakaso, Thomas Partey, Thomas Agyapong, Christian Atsu, Dede Ayew, Jordan Ayew.